Potassium Carbonate → HCID 54012844, 화합물

HRID 1680855노트

반응식

HRID 1680855 반응식
[CH:1]1([C:4]([OH:6])=[O:5])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+].[CH3:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[CH:20]=[C:19]([CH2:24]Br)[CH:18]=[CH:17]2>CC(C)=O>[CH3:13][C:14]1[CH:15]=[C:16]2[C:21](=[CH:22][CH:23]=1)[CH:20]=[C:19]([CH2:24][O:5][C:4]([CH:1]1[CH2:3][CH2:2]1)=[O:6])[CH:18]=[CH:17]2

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 15655Cyclopropanecarboxylic acidHCID 123373022-(Bromomethyl)-6-methylnaphthalene

생성물 1

HCID 54012844HCID 54012844, 화합물

시약·촉매·용매 1

HCID 180Acetone용매2회

반응 조건

온도
50 °C

실험 절차

1.89 g of cyclopropane carboxylic acid are dissolved in 50 ml of acetone, treated with 5.5 g of potassium carbonate and heated to 50° C. A solution of 4.7 g of 6-methyl-2-(bromomethyl)naphthalene in 20 ml of acetone is then added dropwise. The mixture is left to react at 65° C. for 15 hours. The mixture is cooled and filtered. The residue is then rinsed with acetone and the filtrate is evaporated. The residue is purified chromatography on silica gel with hexane/ethyl acetate (9:1) to yield pure cyclopropane carboxylic acid (6-methyl-2-naphthyl)methyl ester of melting point 75°-78° C. (from petane/ether).

후처리

  1. waitThe mixture is left
  2. customto react at 65° C. for 15 hours
  3. temperatureThe mixture is cooled
  4. filtrationfiltered
  5. washThe residue is then rinsed with acetone
  6. customthe filtrate is evaporated
  7. customThe residue is purified chromatography on silica gel with hexane/ethyl acetate (9:1)

출처 및 근거

ORD 기록
ord-5635dae7c6424c1b9c7cfee98d8ce001
출처 데이터셋
uspto-grants-1981_06
특허 번호
US04276305

반응 노트

불러오는 중…