Ammonium Hydroxide → HCID 178516142, 화합물

HRID 1681199노트

반응식

HRID 1681199 반응식
[F:1][C:2]([F:16])([F:15])[C:3](=O)[CH2:4][C:5](=[O:13])[CH2:6][C:7]([C:9]([F:12])([F:11])[F:10])=O.[OH-].[NH4+:18]>>[F:1][C:2]([F:16])([F:15])[C:3]1[CH:4]=[C:5]([OH:13])[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[N:18]=1

참가 물질

3

반응물 2

HCID 14923Ammonium HydroxideHCID 115289171,1,1,7,7,7-Hexafluoroheptane-2,4,6-trione

생성물 1

HCID 178516142HCID 178516142, 화합물

반응 조건

온도
130 °C

실험 절차

A mixture of 30 g 1,5-di(trifluoromethyl)-1,3,5-trioxopentane and 125 ml 28% aqueous ammonium hydroxide was heated in an autoclave at 130° C. for 5 hours. The reaction mixture was concentrated in vacuo, dissolved in 350 ml ethanol and treated with 11 ml 6N hydrochloric acid. The resulting mixture was concentrated in vacuo, 100 ml water added to the residue and filtered to give 8.0 g 2,6-di(trifluoromethyl)-4-hydroxypyridine, m.p. 123°-130° C.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. dissolutiondissolved in 350 ml ethanol
  3. additiontreated with 11 ml 6N hydrochloric acid
  4. concentrationThe resulting mixture was concentrated in vacuo, 100 ml water
  5. additionadded to the residue
  6. filtrationfiltered

출처 및 근거

ORD 기록
ord-dec5f2061bb746b79ca7ef18cd3eadc1
출처 데이터셋
uspto-grants-1992_12
특허 번호
US05169853

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