Benzoic acid, 2-(aminosulfonyl)-, methyl ester → N1-(2,6-dichloro-7-methyl-8-purinyl)-2-carbomethoxybenzenesulfonamide

HRID 1681311

반응식

HRID 1681311 반응식
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[S:11]([NH2:14])(=[O:13])=[O:12])([O:3][CH3:4])=[O:2].N[C:16]1[N:24]([CH3:25])[C:23]2[C:18](=[N:19][C:20]([Cl:27])=[N:21][C:22]=2[Cl:26])[N:17]=1>N1C=CC=CC=1>[Cl:27][C:20]1[N:19]=[C:18]2[C:23]([N:24]([CH3:25])[C:16]([NH:14][S:11]([C:6]3[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=3[C:1]([O:3][CH3:4])=[O:2])(=[O:13])=[O:12])=[N:17]2)=[C:22]([Cl:26])[N:21]=1

참가 물질

4

반응물 2

HCID 42546Benzoic acid, 2-(aminosulfonyl)-, methyl esterHCID 150677208-Amino-2,6-dichloro-7-methylpurine

생성물 1

HCID 15067721N1-(2,6-dichloro-7-methyl-8-purinyl)-2-carbomethoxybenzenesulfonamide

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

At 70° C., 6.60 g (28 mmol) of 2-carbomethoxybenzenesulfonamide was added to a suspension of 3.00 g (14.0 mmol) of 8-amino-2,6-dichloro-7-methylpurine in 150 ml of pyridine. After 3 hours at 70°-80° C., the reaction mixture was evaporated down in a rotary evaporator, and the residue was stirred into ice/H2O and acidified with dilute HCl. The desired product was obtained in the form of a brown powder having the following physical data (active ingredient 1.020)

후처리

  1. customthe reaction mixture was evaporated down in a rotary evaporator

출처 및 근거

ORD 기록
ord-790b502cc08147b19e9c4e7aa119cdda
출처 데이터셋
uspto-grants-1992_12
특허 번호
US05171353

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