Potassium Hydroxide → HCID 19805429, 화합물

HRID 1681689

반응식

HRID 1681689 반응식
[N+:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Br)=[CH:6][CH:5]=1)([O-:3])=[O:2].[C:12]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19](=[O:26])[NH:18]1)([O:14][CH2:15][CH3:16])=[O:13].[OH-].[K+]>C(O)C>[C:12]([N:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C:19](=[O:26])[N:18]1[CH2:8][C:7]1[CH:10]=[CH:11][C:4]([N+:1]([O-:3])=[O:2])=[CH:5][CH:6]=1)([O:14][CH2:15][CH3:16])=[O:13]

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 660114-Nitrobenzyl bromideHCID 584113Ethyl 3-oxo-2,3-dihydro-1H-indazole-1-carboxylate

생성물 1

HCID 19805429HCID 19805429, 화합물수율 59%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

4-Nitrobenzyl bromide (540 mg) was added to a mixture of 1,2-dihydro-1-carboethoxy-3H-indazol-3-one (206 mg) and potassium hydroxide (67 mg) in ethanol (10 ml). The mixture was heated under reflux for 30 minutes. The cooled solution was clarified by filtration and the filtrate was evaporated. The residue was purified by column chromatography using methylene chloride as eluant to give 1,2-dihydro-1-carboethoxy-2-(4-nitrobenzyl)-3H-indazol-3-one (Ex. 39) as a solid, m.p. 123-124° C. in 59% yield.

후처리

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. filtrationThe cooled solution was clarified by filtration
  4. customthe filtrate was evaporated
  5. customThe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-b5a0debec6f14606927ce7535fbf838d
출처 데이터셋
uspto-grants-1992_12
특허 번호
US05173496

연결된 노트

불러오는 중…