Potassium Hydroxide → 99517-24-5

HRID 1681858노트

반응식

HRID 1681858 반응식
[C:1]([C:5]1[C:10]2[O:11][CH:12]=[CH:13][C:9]=2[CH:8]=[C:7]([Cl:14])[CH:6]=1)([O:3]C)=[O:2].[OH-].[K+]>CO>[Cl:14][C:7]1[CH:6]=[C:5]([C:1]([OH:3])=[O:2])[C:10]2[O:11][CH:12]=[CH:13][C:9]=2[CH:8]=1

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 14838646HCID 14838646, 화합물

생성물 1

HCID 1483864799517-24-5수율 94.3%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A solution of 7-carbomethoxy-5-chlorobenzo[b]furan (6c) (3.02 g, 14.3 mmol) containing potassium hydroxide (3.22 g) in 100 ml of aqueous methanol (CH3OH/H2O=3/2) was stirred at room temperature overnight. The mixture was concentrated under reduced pressure. The residue was acidified with conc. HCl to pH of about 1, cooled in freezer for several hours and filtered to give 7c as an off-white solid (2.65 g, 94.3%), mp 212°-215° C. NMR (DMSO-d6) δ8.0-6.87 (m, 5H, aromatic protons and OH).

후처리

  1. concentrationThe mixture was concentrated under reduced pressure
  2. temperaturecooled in freezer for several hours
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-79da8bb4341746ca9fc90baff57ee9e6
출처 데이터셋
uspto-grants-1992_12
특허 번호
US05175173

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