Methanol → 1-Cyclopropylpiperazine

HRID 16819

반응식

HRID 16819 반응식
Cl.Cl.[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1.CO>O>[CH:3]1([N:6]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]2)[CH2:5][CH2:4]1

참가 물질

4

반응물 2

HCID 887MethanolHCID 212208121-Cyclopropylpiperazine dihydrochloride

생성물 1

HCID 47420041-Cyclopropylpiperazine수율 84.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1-Cyclopropylpiperazine dihydrochloride (1.493 g, 7.5 mmol) was dissolved in water (5.00 mL) and methanol (5.00 mL) and converted to its freebase by ion exchange chromatography, using an SCX column. The desired product was eluted from the column using 3.5M ammonia in methanol and pure fractions were evaporated to dryness to afford 1-cyclopropylpiperazine (0.796 g, 84%) as an oil.

후처리

  1. washThe desired product was eluted from the column
  2. customwere evaporated to dryness

출처 및 근거

ORD 기록
ord-52133c47f1534988bfc9e04dd961a467
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737149B2

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