4,5-Dichlorophthalic anhydride → 2-Carbomethoxy 4,5-dichlorobenzoic acid

HRID 1681943

반응식

HRID 1681943 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[O:10])[O:8][C:6](=[O:7])[C:5]2=[CH:11][C:12]=1[Cl:13].[CH3:14][O-:15].[Na+]>CO>[C:6]([C:5]1[CH:11]=[C:12]([Cl:13])[C:2]([Cl:1])=[CH:3][C:4]=1[C:9]([OH:8])=[O:10])([O:15][CH3:14])=[O:7]

참가 물질

4

반응물 2

HCID 703344,5-Dichlorophthalic anhydrideHCID 10942334Sodium Methoxide

생성물 1

HCID 198042632-Carbomethoxy 4,5-dichlorobenzoic acid수율 92.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 4,5-dichlorophthalic anhydride (1.0 g, 4.61 mmol) in 15 mL of methanol was added 0.25 g (9.22 mmol, 2.0 eq) of sodium methoxide. The suspension was stirred for 3 days and the methanol was removed in vacuo. The resultant white solid was suspended in 500 mL of CH2Cl2 and washed with 1N HCl. The organic phase was dried over anhydrous Na2SO4, filtered and the volatiles removed in vacuo to yield 1.06 g (92.5%) of the titled compound as a white powder.

후처리

  1. customthe methanol was removed in vacuo
  2. washwashed with 1N HCl
  3. dry with materialThe organic phase was dried over anhydrous Na2SO4
  4. filtrationfiltered
  5. customthe volatiles removed in vacuo

출처 및 근거

ORD 기록
ord-f6fa263ca617444e8bd8f293493ce640
출처 데이터셋
uspto-grants-1992_12
특허 번호
US05175164

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