1-(3-Chloropropoxy)-3-methylbenzene → 2-[2-(N-(3-(3-Methyl-phenoxy)-propyl)-piperid-2-yl)-ethyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

HRID 1682030노트

반응식

HRID 1682030 반응식
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][CH2:8][N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:19][CH3:20])[CH:15]=2)[C:10]1=[O:23].[Cl:24][CH2:25][CH2:26][CH2:27][O:28][C:29]1[CH:34]=[CH:33][CH:32]=[C:31]([CH3:35])[CH:30]=1>>[ClH:24].[CH3:35][C:31]1[CH:30]=[C:29]([CH:34]=[CH:33][CH:32]=1)[O:28][CH2:27][CH2:26][CH2:25][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[CH2:7][CH2:8][N:9]1[CH2:18][CH2:17][C:16]2[C:11](=[CH:12][C:13]([O:21][CH3:22])=[C:14]([O:19][CH3:20])[CH:15]=2)[C:10]1=[O:23]

참가 물질

3

반응물 2

HCID 127603061-(3-Chloropropoxy)-3-methylbenzeneHCID 198037012-[2-(Piperid-2-yl)-ethyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline

생성물 1

HCID 198037472-[2-(N-(3-(3-Methyl-phenoxy)-propyl)-piperid-2-yl)-ethyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

실험 절차

Prepared from 2-[2-(piperid-2-yl)-ethyl]-6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline and 1-chloro-3-(3-methyl-phenoxy)-propane analogously to Example 1.

출처 및 근거

ORD 기록
ord-84924f095aba4f6a8df3519172b2382f
출처 데이터셋
uspto-grants-1992_12
특허 번호
US05175157

반응 노트

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