Noroxyhydrastinine → 2-[(N-(3-(Pyrid-3-yl)-propyl)-piperidin-3-yl)-methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

반응식

[CH2:1]1[O:13][C:12]2[CH:11]=[C:10]3[C:5]([CH2:6][CH2:7][NH:8][C:9]3=[O:14])=[CH:4][C:3]=2[O:2]1.[Cl:15][CH2:16][CH:17]1[CH2:22][CH2:21][CH2:20][N:19]([CH2:23][CH2:24][CH2:25][C:26]2[CH:27]=[N:28][CH:29]=[CH:30][CH:31]=2)[CH2:18]1>>[ClH:15].[N:28]1[CH:29]=[CH:30][CH:31]=[C:26]([CH2:25][CH2:24][CH2:23][N:19]2[CH2:20][CH2:21][CH2:22][CH:17]([CH2:16][N:8]3[CH2:7][CH2:6][C:5]4[C:10](=[CH:11][C:12]5[O:13][CH2:1][O:2][C:3]=5[CH:4]=4)[C:9]3=[O:14])[CH2:18]2)[CH:27]=1

참가 물질

반응물 2

HCID 89047Noroxyhydrastinine

HCID 19803735HCID 19803735, 화합물

생성물 1

HCID 198039932-[(N-(3-(Pyrid-3-yl)-propyl)-piperidin-3-yl)-methyl]-6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline-hydrochloride

실험 절차

Prepared from 6,7-methylenedioxy-1-oxo-1,2,3,4-tetrahydro-isoquinoline and 3-chloromethyl-N-[3-(pyrid-3-yl)-propyl]-piperidine analogously to Example 2.

출처 및 근거

ORD 기록: ord-043c5cd8f51c4a0b9ffeb7b4618a8982
출처 데이터셋: uspto-grants-1992_12
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05175157

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