Sodium Methoxide → N-benzoyl-3-methoxycaprolactam

HRID 1682379노트

반응식

HRID 1682379 반응식
ClC1CCCNC(=O)C1.C[O-].[Na+].[C:13]([N:21]1[CH2:26][CH2:25]O[CH2:23][C:22]1=[O:27])(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH3:28][O:29][CH:30]1[CH2:37][CH2:36][CH2:35][NH:34][C:32](=[O:33])[CH2:31]1>>[CH3:28][O:29][CH:30]1[CH2:37][CH2:36][CH2:35][NH:34][C:32](=[O:33])[CH2:31]1.[C:13]([N:21]1[CH2:26][CH2:25][CH2:31][CH:30]([O:29][CH3:28])[CH2:23][C:22]1=[O:27])(=[O:20])[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

참가 물질

6

반응물 4

HCID 10942334Sodium MethoxideHCID 122940964-Benzoylmorpholin-3-oneHCID 190438224-Methoxyazepan-2-oneHCID 193693183-Chlorocaprolactam

생성물 2

HCID 19043821N-benzoyl-3-methoxycaprolactamHCID 190438224-Methoxyazepan-2-one

실험 절차

3-Methoxycaprolactam was prepared from 3-chlorocaprolactam (prepared as described in Francis, et al. J. Am. Chem. Soc. 1958, 80, 6238) and sodium methoxide according to the method of Kondelikova, et al. (Collect. Czech. Chem. Commun. 1971, 36(9), 3391). The desired product N-benzoyl-3-methoxycaprolactam is synthesized as for N-benzoyl-3-oxomorpholine (Example I) using 3 -methoxycaprolactam in place of morpholin-3-one.

출처 및 근거

ORD 기록
ord-9aa69dbbb2814954beb15485a083d590
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05635103

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