Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Pyridine-2-carbothioamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| 반응물 | 2-Pyridinecarboxamide | HCID 15070 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | Pyridine-2-carbothioamide | HCID 1549499 | 74.8% |
반응 단계
43 g of phosphorus pentasulfide were added slowly to 46.8 g of the amide of Stage A in 700 ml of tetrahydrofuran and the mixture was stirred for 4 hours at ambient temperature. The reaction mixture was poured into water and extracted with ether. The extracts were dried and the solvent was evaporated under reduced pressure. After chromatography on silica (eluant: CH2Cl2 --AcOEt 8-2), 10 g of expected product melting at 137° C. were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05635485 |
| 출처 데이터셋 | uspto-grants-1997_06 |
| ORD ID | ord-189d08015cd14c07b7bc2532edc628c1 |
| 출처 메모 | uspto-grants-1997_06 |