N4-Acetylsulfanilamide → trans-6-(4-Acetylaminobenzenesulfonamido)-1,3-dioxepane-5-ol

HRID 1682556

반응식

HRID 1682556 반응식
[O:1]1[CH:8]2[CH:2]1[CH2:3][O:4][CH2:5][O:6][CH2:7]2.[C:9]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([S:19]([NH2:22])(=[O:21])=[O:20])=[CH:15][CH:14]=1)(=[O:11])[CH3:10]>>[C:9]([NH:12][C:13]1[CH:14]=[CH:15][C:16]([S:19]([NH:22][C@@H:2]2[CH2:3][O:4][CH2:5][O:6][CH2:7][C@H:8]2[OH:1])(=[O:20])=[O:21])=[CH:17][CH:18]=1)(=[O:11])[CH3:10]

참가 물질

3

반응물 2

HCID 8482N4-AcetylsulfanilamideHCID 114007463,5,8-Trioxabicyclo[5.1.0]octane

생성물 1

HCID 67615689trans-6-(4-Acetylaminobenzenesulfonamido)-1,3-dioxepane-5-ol

실험 절차

A mixture of 5,6-epoxy-1,3-dioxepane (0.5 g) and of 4-acetylaminobenzenesulfonamide (0.92 g) was heated in a sealed ampule at the temperature of 150° C. for 15 minutes. The mixture was cooled to room temperature, chromatographed on a silica gel column by elution with a mixture of ethyl acetate-methanol (9.5:0.5) and trans-6-(4-acetylaminobenzenesulfonamido)-1,3-dioxepane-5-ol was obtained. M.p. 208°-210° C./ethyl acetate-methanol (6:1).

후처리

  1. customchromatographed on a silica gel column by elution with a mixture of ethyl acetate-methanol (9.5:0.5)

출처 및 근거

ORD 기록
ord-7b3beacd348c46479227d49b0b57b345
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05635529

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