5-cyanobenzofuran-2-carboxylic Acid → HCID 178451372, 화합물

HRID 1682666노트

반응식

HRID 1682666 반응식
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([OH:13])=O)=[CH:8][C:7]=2[CH:14]=1)#[N:2].[NH2:15][C@H:16]1[CH2:21][CH2:20][C@H:19]([O:22][CH2:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:18][CH2:17]1>>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:10][C:9]([C:11]([NH:15][C@H:16]3[CH2:21][CH2:20][C@H:19]([O:22][CH2:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:18][CH2:17]3)=[O:13])=[CH:8][C:7]=2[CH:14]=1)#[N:2]

참가 물질

3

반응물 2

HCID 102360545-cyanobenzofuran-2-carboxylic AcidHCID 178451370HCID 178451370, 화합물

생성물 1

HCID 178451372HCID 178451372, 화합물수율 78%

실험 절차

The same method as in Example 18 was employed. That is, 5-cyano-2-benzofurancarboxylic acid (749 mg, 4.00 mmol) and t-butyl trans-(4-aminocyclohexyloxy)acetate (917 mg, 4.00 mmol) were condensed to give 1.24 g of t-butyl trans-[4-[(5-cyano-2-benzofuranyl)carbonylamino]cyclohexyloxy]acetate as a colorless solid (78%).

후처리

  1. customcondensed

출처 및 근거

ORD 기록
ord-386c2ef0b7d94ac7b1cc659ebc7e5950
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05635527

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