반응식
C([O:4][CH:5]([C:33]1[N:37]([C:38]2[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=2)[N:36]=[CH:35][CH:34]=1)[CH:6]([C:25]1[CH:30]=[CH:29][C:28]([Cl:31])=[C:27]([Cl:32])[CH:26]=1)[CH2:7][CH2:8][N:9]1[CH2:14][CH2:13][C:12]([NH:21][C:22](=[O:24])[CH3:23])([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH2:11][CH2:10]1)(=O)C.C(NC1(C2C=CC=CC=2)CCNCC1)(=O)C.C(OC(C1N(C2C=CC=CC=2)N=CC=1)C(C1C=CC(Cl)=C(Cl)C=1)CC=O)(=O)C>>[Cl:32][C:27]1[CH:26]=[C:25]([CH:6]([CH2:7][CH2:8][N:9]2[CH2:14][CH2:13][C:12]([NH:21][C:22](=[O:24])[CH3:23])([C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:11][CH2:10]2)[CH:5]([C:33]2[N:37]([C:38]3[CH:43]=[CH:42][CH:41]=[CH:40][CH:39]=3)[N:36]=[CH:35][CH:34]=2)[OH:4])[CH:30]=[CH:29][C:28]=1[Cl:31]참가 물질
4
반응물 3
생성물 1
실험 절차
5-[(1RS,2RS)-1-Acetoxy-2-(3,4-dichlorophenyl)-4-(4-acetamido-4-phenylpiperidino)butyl]-1-phenylpyrazole. Using a procedure similar to that described in Example 7, except using 4-acetamido-4-phenylpiperidine as the amine component and 5-[(1RS,2RS)-1-acetoxy-2-(3,4-dichlorophenyl)-4-oxobutyl]-1-phenylpyrazole as the aldehyde component, the title compound was obtained as a white foam (65%; NMR: 7.58 (d,1), 7.48-7.21 (m,11), 7.09 (d, 1), 6.81 (dd, 1), 6.22 (d, 1), 6.09 (d, 1), 5.39 (s,1), 3.06 (m,1), 2.51 (m,2), 2.31 (m,2), 2.15-2.00 (m,7), 1.98 (s,3), 1.96 (s,3), 1.75 (m,1), 1.43 (m,1).
출처 및 근거
- ORD 기록
- ord-fb5a0f949ba840478c93d3ae0ba630dc
- 출처 데이터셋
- uspto-grants-1997_06
- 특허 번호
- US05635509
연결된 노트
불러오는 중…