Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → 2-[3-(3,4-Dichloro-phenyl)-1-(3,5-bis-(trifluoromethyl)-benzoyl)-pyrrolidin-3-yl]-ethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 3,5-Bis(trifluoromethyl)benzoyl chloride | HCID 101856 | — |
| 반응물 | 2-(3-(3,4-Dichlorophenyl)pyrrolidin-3-yl)ethanol | HCID 18464427 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 2-[3-(3,4-Dichloro-phenyl)-1-(3,5-bis-(trifluoromethyl)-benzoyl)-pyrrolidin-3-yl]-ethanol | HCID 18333361 | — |
반응 단계
The method of example 3.1 was used with 2-[3-(3,4-dichloro-phenyl)-pyrrolidin-3-yl]-ethanol (1 mmol) and 3,5-bis(trifluoromethyl)-benzoyl chloride (1 mmol) to obtain a residue. Chromatography of the residue on silica gel eluting sequentially with 1% methanol in dichloromethane and then 6% methanol in dichloromethane gave the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05635510 |
| 출처 데이터셋 | uspto-grants-1997_06 |
| ORD ID | ord-dd659d48b57f463ba16bbe35cf609478 |
| 출처 메모 | uspto-grants-1997_06 |