Methanol → Methyl 4-phenylpiperidine-4-carboxylate hydrochloride
반응식
Cl.[C:2]1([C:8]2([C:14]([OH:16])=[O:15])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17]O.O=S(Cl)[Cl:21]>C(OCC)C>[ClH:21].[CH3:17][O:15][C:14]([C:8]1([C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)=[O:16]참가 물질
5
실험 절차
4-phenyl-piperidine-4-carboxylic acid hydrochloride (from example 20.6) (2.67 g, 11 mmol) and methanol (35 mL) were combined. SOCl2 (0.9 mL, 12.34 mmol, 1.1 eq.) was added dropwise. The reaction was heated at reflux for 18 h. The reaction was concentrated in vacuo to obtain a residue. The residue was slurried in diethyl ether, filtered, and the solids were rinsed with diethyl ether to give the title compound.
후처리
- temperatureThe reaction was heated
- temperatureat reflux for 18 h
- concentrationThe reaction was concentrated in vacuo
- customto obtain a residue
- filtrationfiltered
- washthe solids were rinsed with diethyl ether
출처 및 근거
- ORD 기록
- ord-5bdd2c66613f4fe880bd72984130e3bc
- 출처 데이터셋
- uspto-grants-1997_06
- 특허 번호
- US05635510
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