Formic Acid → HCID 86750935, 화합물

반응식

C(N[C:4]1[C:9]2[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:8]=2[CH:7]=[CH:6][CH:5]=1)C.[CH:15]([OH:17])=O.[CH2:18]([N:20](CC)CC)[CH3:19]>>[CH:15]([NH:20][CH2:18][CH2:19][C:4]1[C:9]2[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:8]=2[CH:7]=[CH:6][CH:5]=1)=[O:17]

참가 물질

반응물 3

HCID 284Formic Acid

HCID 8471Triethylamine

HCID 19043049HCID 19043049, 화합물

생성물 1

HCID 86750935HCID 86750935, 화합물

실험 절차

1-Ethylamino-benzocycloheptane (1 g, 5.3 mmol) was treated with formic acid (1.22 ml, 32 mmol) and triethylamine (1 ml, 7.2 mmol) and the mixture was heated under reflux for 22 hours under an argon atmosphere. After cooling to room temperature, the mixture was partitioned between diethyl ether (165 ml) and 5% aqueous NaHCO3 (100 ml). The organic layer was separated, dried (Na2SO4) and evaporated to a brown oil (1.06 g, 93%)

후처리

temperaturethe mixture was heated
temperatureunder reflux for 22 hours under an argon atmosphere
customthe mixture was partitioned between diethyl ether (165 ml) and 5% aqueous NaHCO3 (100 ml)
customThe organic layer was separated
dry with materialdried (Na2SO4)
customevaporated to a brown oil (1.06 g, 93%)

출처 및 근거

ORD 기록: ord-3bbbe30c805a4a70b3f00e1bc127625b
출처 데이터셋: uspto-grants-1997_06
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05637609

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