Acetone → 2-Amino-4-(4-chlorophenacyl)-1-(2-morpholinoethyl)benzimidazolium bromide

HRID 1683723

반응식

HRID 1683723 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Br:8])=[CH:4][CH:3]=1.[NH2:9][C:10]1[N:14]([CH2:15][CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[C:13]2[CH:23]=[CH:24][CH:25]=[CH:26][C:12]=2[N:11]=1.[CH3:27][C:28](C)=[O:29]>>[Br-:8].[NH2:9][C:10]1[NH:11][C:12]2[C:26]([CH2:27][C:28]([C:5]3[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=3)=[O:29])=[CH:25][CH:24]=[CH:23][C:13]=2[N+:14]=1[CH2:15][CH2:16][N:17]1[CH2:18][CH2:19][O:20][CH2:21][CH2:22]1

참가 물질

4

반응물 3

HCID 180Acetone2회HCID 7806p-BromochlorobenzeneHCID 5680111-(2-Morpholin-4-ylethyl)-2-aminobenzimidazole

생성물 1

HCID 677118142-Amino-4-(4-chlorophenacyl)-1-(2-morpholinoethyl)benzimidazolium bromide수율 95%

실험 절차

A solution of 2.33 g (10 mmol) of 4-chlorophenyl bromide in 25 ml of acetone is added to a hot solution of 2-amino-1-(2-morpholinoethyl)benzimidazole (2.46 g, 10 mmol) in 75 ml of acetone. The mixture is stirred, heated at the boil for 5 minutes and maintained at room temperature. Three hours later a precipitate of the title compound appears, which is filtered and washed with acetone and with ether.

후처리

  1. temperatureheated at the boil for 5 minutes
  2. customThree hours

출처 및 근거

ORD 기록
ord-d328db2353664cdfb4c554499c78cf66
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05639756

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