1-(Triphenylphosphoranylidene)acetone → [1-(3-Oxobut-1-en-1-yl)cyclopropyl]acetonitrile

HRID 1683980노트

반응식

HRID 1683980 반응식
O=[CH:2][CH2:3][C:4]1([CH2:7][C:8]#[N:9])[CH2:6][CH2:5]1.C1(P(C2C=CC=CC=2)(C2C=CC=CC=2)=[CH:17][C:18](=[O:20])C)C=CC=CC=1>C1COCC1>[O:20]=[C:18]([CH3:17])[CH:2]=[CH:3][C:4]1([CH2:7][C:8]#[N:9])[CH2:6][CH2:5]1

참가 물질

4

반응물 2

HCID 150381-(Triphenylphosphoranylidene)acetoneHCID 19041707[1-(2-Oxoethyl)cyclopropyl]acetonitrile

생성물 1

HCID 53970073[1-(3-Oxobut-1-en-1-yl)cyclopropyl]acetonitrile수율 92.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of the aldehyde from Example 1, Step 2 (8.12 g, 75 mmol) and 1-triphenylphosphoranylidene-2-propanone (26.4 g, 83 mmol) in 250 mL THF was heated to reflux overnight. The reaction mixture was partitioned between 1N HCl and ethyl acetate, and the organic layer was washed with brine, dried over MgSO4 and evaporated. Et2O was added to the residue, the phosphine oxide was filtered off and the solvent removed in vacuo. Purification through a plug of silica gel provided 10.3 g of the title compound.

후처리

  1. temperaturewas heated
  2. temperatureto reflux overnight
  3. customThe reaction mixture was partitioned between 1N HCl and ethyl acetate
  4. washthe organic layer was washed with brine
  5. dry with materialdried over MgSO4
  6. customevaporated
  7. additionEt2O was added to the residue
  8. filtrationthe phosphine oxide was filtered off
  9. customthe solvent removed in vacuo
  10. customPurification through a plug of silica gel

출처 및 근거

ORD 기록
ord-2d4d291cacaa40c3805014381948b90c
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05639780

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