[1-(3-Oxobut-1-en-1-yl)cyclopropyl]acetonitrile → [1-(3-Oxobutan-1-yl)cyclopropyl]acetonitrile

HRID 1683981노트

반응식

HRID 1683981 반응식
[O:1]=[C:2]([CH3:11])[CH:3]=[CH:4][C:5]1([CH2:8][C:9]#[N:10])[CH2:7][CH2:6]1.[H][H]>C(OCC)(=O)C.[Pd]>[O:1]=[C:2]([CH3:11])[CH2:3][CH2:4][C:5]1([CH2:8][C:9]#[N:10])[CH2:7][CH2:6]1

참가 물질

5

반응물 2

HCID 53970073[1-(3-Oxobut-1-en-1-yl)cyclopropyl]acetonitrileHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 19041667[1-(3-Oxobutan-1-yl)cyclopropyl]acetonitrile수율 101.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

A solution of the olefin from Step 1 (4.08 g, 26.8 mmol) in 85 mL ethyl acetate was treated with 30 psi hydrogen over 5% palladium on carbon (300 rag) in a Parr shaker for 1.5 h. The mixture was filtered through celite and evaporated to give 4.1 g of the title compound.

후처리

  1. filtrationThe mixture was filtered through celite
  2. customevaporated

출처 및 근거

ORD 기록
ord-2694639149ec464c8d04aacd39c273a7
출처 데이터셋
uspto-grants-1997_06
특허 번호
US05639780

반응 노트

불러오는 중…