Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → HCID 19041650, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 4-(1-(4-Bromobenzyl)-5-methoxy-2-methyl-1H-indol-3-yl)-3-methylbutanoic acid | HCID 9867333 | — |
| 용매 | Benzene | HCID 241 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 19041650 | HCID 19041650 | — |
반응 단계
To the acid of Example 7, Step 6, (600 mg, 1.39 mmol) in benzene (10.0 mL) was added at 0° C. DMF (50 mL) and oxalyl chloride. After a period of 30 min at 0° /C., THF (10.0 mL) was added to the resulting mixture and ammonia gas was bubbled until saturation. The mixture was stirred for 4 h at r.t. The reaction was poured over water, extracted with EtOAc, dried over Na2SO4, evaporated in vacuo and filtered over silica gel (50% EtOAc in THF) to provide the desired amide (530 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05639780 |
| 출처 데이터셋 | uspto-grants-1997_06 |
| ORD ID | ord-123036ca79af4ffc871ceb1d5ffa7a11 |
| 출처 메모 | uspto-grants-1997_06 |