Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → (R)-3-(N-Isopropylamino)-5-methoxychroman
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | (R)-5-methoxychroman-3-amine | HCID 10845076 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (R)-3-(N-Isopropylamino)-5-methoxychroman | HCID 10489181 | — |
반응 단계
(R)-3-Amino-5-methoxychroman (1.0 g; 6 mmol) and acetone (2.5 g; 40 mmol) were mixed with methanol (820 ml), acetic acid (0.4 g; 6.6 mmol) and NaCNBH3 (1.2 g; 19 mmol), pH was adjusted to 6.0 with acetic acid. Stirring was continued at room temperature for 3 days. The mixture was evaporated and the residue was made alkaline and extracted with CH2Cl2. After drying (Na2SO4) and evaporation the title compound as base was transformed to the HCl-salt. Yield: 1.1 g (83%). Mp: 289° dec. [α]D25 =-29° (C=0.015; MeOH)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05639784 |
| 출처 데이터셋 | uspto-grants-1997_06 |
| ORD ID | ord-dd62e1a50cd0457aa3a30b0a2d52eae4 |
| 출처 메모 | uspto-grants-1997_06 |