Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2,3,4-Tetrahydro-6,7,8-trimethoxyisoquinoline → 2-[7-(3,4-Dimethoxyphenyl)-7-[(4-methylphenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7,8-trimethoxyisoquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2,3,4-Tetrahydro-6,7,8-trimethoxyisoquinoline | HCID 192723 | — |
| 반응물 | 4-[6-Bromo-1-[(4-methylphenyl)thio]heptyl]-1,2-dimethoxybenzene | HCID 19042093 | — |
| 반응물 | 5,6-Dimethoxyisoindoline | HCID 20074351 | — |
| 생성물 | 2-[7-(3,4-Dimethoxyphenyl)-7-[(4-methylphenyl)thio]heptyl]-1,2,3,4-tetrahydro-6,7,8-trimethoxyisoquinoline | HCID 10650882 | 65.7% |
반응 단계
The procedure of Example 49 is repeated using 5.31 g 4-[6-bromo-1-[(4-methylphenyl)thio]heptyl]-1,2-dimethoxybenzene, 3.29 g of 5,6-dimethoxyisoindoline and 2.65 g of 6,7,8-trimethoxy-1,2,3,4-tetrahydroisoquinoline. This affords 4.52 g of the desired product as a yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05639887 |
| 출처 데이터셋 | uspto-grants-1997_06 |
| ORD ID | ord-2caf9163a5a9445eb7b72994b6edb205 |
| 출처 메모 | uspto-grants-1997_06 |