Butylamine → N2-butyl-9H-purine-2,6-diamine

HRID 1684963노트

반응식

HRID 1684963 반응식
Cl[C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH2:11])[N:3]=1.[CH2:12]([NH2:16])[CH2:13][CH2:14][CH3:15]>>[CH2:12]([NH:16][C:2]1[N:10]=[C:9]2[C:5]([NH:6][CH:7]=[N:8]2)=[C:4]([NH2:11])[N:3]=1)[CH2:13][CH2:14][CH3:15]

참가 물질

3

반응물 2

HCID 8007ButylamineHCID 949042-Chloroadenine

생성물 1

HCID 3487963N2-butyl-9H-purine-2,6-diamine수율 30%

실험 절차

2-Chloroadenine (6.0 g, 35.4 mmol) and n-butylamine (30 ml) were reacted in an autoclave (200 ml) at 130° C. for 150 hours. After the reaction mixture was concentrated under reduced pressure, the residue was poured into water to precipitate the solid. The precipitated solid was successively washed with methylene chloride and methanol to give the captioned compound (2.08 g, yield 30%) as a yellowish orange powdered solid.

후처리

  1. concentrationAfter the reaction mixture was concentrated under reduced pressure
  2. additionthe residue was poured into water
  3. customto precipitate the solid
  4. washThe precipitated solid was successively washed with methylene chloride and methanol

출처 및 근거

ORD 기록
ord-5120daebfcee4199a866e8c799b01124
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148371B2

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