Isoamyl mercaptan → {4-[6-(3-Methylbutylsulfanyl)pyridazin-3-YL]piperazin-1-YL}-(2-trifluoromethyl-phenyl)methanone
반응식
[CH3:1][CH:2]([CH3:6])[CH2:3][CH2:4][SH:5].C1(CCS)C=CC=CC=1.Cl[C:17]1[N:22]=[N:21][C:20]([N:23]2[CH2:28][CH2:27][N:26]([C:29]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[C:37]([F:40])([F:39])[F:38])=[O:30])[CH2:25][CH2:24]2)=[CH:19][CH:18]=1>>[CH3:1][CH:2]([CH3:6])[CH2:3][CH2:4][S:5][C:17]1[N:22]=[N:21][C:20]([N:23]2[CH2:24][CH2:25][N:26]([C:29]([C:31]3[CH:36]=[CH:35][CH:34]=[CH:33][C:32]=3[C:37]([F:38])([F:40])[F:39])=[O:30])[CH2:27][CH2:28]2)=[CH:19][CH:18]=1참가 물질
4
실험 절차
Following the procedure set forth above in Example 6, only making variations using 3-methylbutane-1-thiol to replace 2-phenylethanethiol to react with [4-(6-chloropyridazin-3-yl)piperazin-1-yl]-(2-trifluoromethylphenyl)methanone, the title compound was obtained as a white solid (24.3 mg, 26.4% yield). 1H NMR (400 MHz, CDCl3) δ 8.04, 7.98, 6.99, 3.79, 3.56, 3.45-3.47, 3.40, 1.85-1.87, 1.52, 0.72-0.80, 0.46-0.48, 0.09-0.10.
출처 및 근거
- ORD 기록
- ord-cb0ce913d38642ed819ed908b888a617
- 출처 데이터셋
- uspto-grants-2012_04
- 특허 번호
- US08148378B2
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