2-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1) → HCID 58055090, 화합물

HRID 1685002노트

반응식

HRID 1685002 반응식
Cl[C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1Cl)[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][Cl:16])[N:14]=1)=[O:8].Cl.ClCC1N=C(N)SC=1.[F:30]C1C=C(C=CC=1)CN=C=O>>[Cl:16][CH2:15][C:13]1[N:14]=[C:10]([NH:9][C:7]([NH:6][CH2:5][C:4]2[CH:17]=[CH:18][CH:19]=[C:2]([F:30])[CH:3]=2)=[O:8])[S:11][CH:12]=1

참가 물질

4

반응물 3

HCID 732282-Thiazolamine, 4-(chloromethyl)-, hydrochloride (1:1)HCID 6434993-Fluorobenzyl isocyanateHCID 58055096HCID 58055096, 화합물

생성물 1

HCID 58055090HCID 58055090, 화합물

실험 절차

Prepared by same procedure described for Intermediate 2 with 4-(chloromethyl)thiazol-2-amine hydrochloride and 3-fluorobenzyl isocyanate. 1H-NMR (ppm, DMSO-d6): 10.70 (bs, 1H), 7.36 (dd, 1H), 7.07 (m, 4H), 4.63 (s, 2H), 4.34 (d, 2H).

후처리

  1. customPrepared by same procedure

출처 및 근거

ORD 기록
ord-7f69ac5d3f864563886c23263fddecd9
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148380B2

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