Sodium Iodide → HCID 58055059, 화합물

HRID 1685006노트

반응식

HRID 1685006 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15]Cl)[N:14]=1)=[O:8].[I-:21].[Na+]>CC(C)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][I:21])[N:14]=1)=[O:8]

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 58055096HCID 58055096, 화합물2회

생성물 1

HCID 58055059HCID 58055059, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a solution of 1-(3,4-dichlorobenzyl)-3-(4-(chloromethyl)thiazol-2-yl)urea (Intermediate 2, 1 eq) in acetone was added sodium iodide (10 eq) at once. The mixture was stirred at room temperature for 2 h. The volatiles were removed in vacuo and the mixture was taken up in water and EtOAc. The layers were separated and the organic phase was washed with water and brine, dried over Na2SO4, and concentrated in vacuo to afford 1-(3,4-dichlorobenzyl)-3-(4-(iodomethyl)thiazol-2-yl)urea as a tan-colored solid.

후처리

  1. customThe volatiles were removed in vacuo
  2. customThe layers were separated
  3. washthe organic phase was washed with water and brine
  4. dry with materialdried over Na2SO4
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-18b048a0e4c54914a961b8aa45848a42
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148380B2

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