Isopropylamine → HCID 86661277, 화합물

HRID 1685008노트

반응식

HRID 1685008 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15]I)[N:14]=1)=[O:8].[CH:21]([NH2:24])([CH3:23])[CH3:22]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][NH:24][CH:21]([CH3:23])[CH3:22])[N:14]=1)=[O:8]

참가 물질

4

반응물 2

HCID 6363IsopropylamineHCID 58055059HCID 58055059, 화합물

생성물 1

HCID 86661277HCID 86661277, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The 1-(3,4-Dichloro-benzyl)-3-(4-iodomethyl-thiazol-2-yl)-urea intermediate (0.3 mmol) was taken up in tetrahydrofuran (5 ml) and isopropyl amine (20 eq.) was added. The reaction was stirred overnight at room temperature. Added a saturated solution of NaSO3 (40 ml). Extracted this with EtOAc twice. The combined organic extracts were dried over Na2SO4, filtered and solvent removed in vacuo. The crude 1-(3,4-dichlorobenzyl)-3-(4-((isopropylamino)methyl)thiazol-2-yl)urea was used as is.

후처리

  1. extractionExtracted this with EtOAc twice
  2. dry with materialThe combined organic extracts were dried over Na2SO4
  3. filtrationfiltered
  4. customsolvent removed in vacuo

출처 및 근거

ORD 기록
ord-bec7f25a0b004b0f8d13a8dbeceae07b
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148380B2

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