2-Methoxyethylamine → HCID 25051699, 화합물

HRID 1685013노트

반응식

HRID 1685013 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15]Cl)[N:14]=1)=[O:8].[CH3:21][O:22][CH2:23][CH2:24][NH2:25]>CN1C(=O)CCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:17]=[CH:18][C:19]=1[Cl:20])[CH2:5][NH:6][C:7]([NH:9][C:10]1[S:11][CH:12]=[C:13]([CH2:15][NH:25][CH2:24][CH2:23][O:22][CH3:21])[N:14]=1)=[O:8]

참가 물질

4

반응물 2

HCID 80182-MethoxyethylamineHCID 58055096HCID 58055096, 화합물2회

생성물 1

HCID 25051699HCID 25051699, 화합물

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

반응 조건

온도
80 °C

실험 절차

1-(4-Chloromethyl-thiazol-2-yl)-3-(3,4-dichloro-benzyl)-urea (Intermediate 2, 1 eq.) was taken up in NMP (0.3 M) and methoxyethylamine (2.2 eq.) was added. The reaction was heated overnight at 80° C. An aqueous workup was performed. The crude title compound was purified by column chromatography using 0-8% gradient of 7 N ammonia/MeOH and DCM.

후처리

  1. customThe crude title compound was purified by column chromatography

출처 및 근거

ORD 기록
ord-20b6fe37be9648f389d072c4f32f318e
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148380B2

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