Trifluoroacetic acid → (R)-tetrahydro-furan-2-carboxylic acid (2-amino-thiazol-4-ylmethyl)-methyl-amide

HRID 1685069노트

반응식

C(OC(=O)[NH:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][N:14]([CH3:22])[C:15]([C@H:17]2[CH2:21][CH2:20][CH2:19][O:18]2)=[O:16])[N:12]=1)(C)(C)C.C(O)(C(F)(F)F)=O>>[NH2:7][C:8]1[S:9][CH:10]=[C:11]([CH2:13][N:14]([CH3:22])[C:15]([C@H:17]2[CH2:21][CH2:20][CH2:19][O:18]2)=[O:16])[N:12]=1

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 86661307(4-{[methyl-((R)-tetrahydro-furan-2-carbonyl)-amino]-methyl}-thiazol-2-yl)-carbamic acid tert-butyl ester

생성물 1

HCID 86661308(R)-tetrahydro-furan-2-carboxylic acid (2-amino-thiazol-4-ylmethyl)-methyl-amide

실험 절차

The product from Step 1 was treated with TFA to cleave the BOC group (Method 1) to afford (R)-tetrahydro-furan-2-carboxylic acid (2-amino-thiazol-4-ylmethyl)-methyl-amide.

출처 및 근거

ORD 기록: ord-bb597e1ad90f430a8deee0472d118142
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08148380B2

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