Morpholine → 6-(Morpholin-4-yl)pyridin-2-amine

반응식

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>>[O:12]1[CH2:13][CH2:14][N:9]([C:4]2[N:3]=[C:2]([NH2:1])[CH:7]=[CH:6][CH:5]=2)[CH2:10][CH2:11]1

참가 물질

반응물 2

HCID 8083Morpholine

HCID 2062462-Amino-6-chloropyridine

생성물 1

HCID 187718606-(Morpholin-4-yl)pyridin-2-amine

반응 조건

온도: 225 °C

실험 절차

A mixture of 2-amino-6-chloropyridine in 100 mL of morpholine was heated at 225° C. for 60 mins. The mixture was cooled and precipitate filtered off, the filtrate was concentrated to give the 17 gram product as a brown oil.

후처리

temperatureThe mixture was cooled
filtrationprecipitate filtered off
concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록: ord-5420d8f6d19e4bcf92b4bfd6b98332b2
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08148367B2

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