Diisopropylethylamine → 4-{4-[4-(3,4-Difluoro-phenyl)-1-(2-dimethylamino-ethyl)-1H-imidazol-2-yl]-piperidin-1-yl}-5-ethyl-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one

참여 물질

역할	이름	HCID	투입량
반응물	Diisopropylethylamine	HCID 81531	—
반응물	4-Chloro-5-ethyl-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one	HCID 59322362	—
반응물	4-(3,4-difluorophenyl)-2-(piperidin-4-yl)-1H-imidazol-1-yl-N,N-dimethyl ethanamine	HCID 67264707	—
용매	Isopropanol	HCID 3776	—
생성물	4-{4-[4-(3,4-Difluoro-phenyl)-1-(2-dimethylamino-ethyl)-1H-imidazol-2-yl]-piperidin-1-yl}-5-ethyl-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one	HCID 59322456	26.2%

반응 단계

Combine 2-(4-(3,4-difluorophenyl)-2-(piperidin-4-yl)-1H-imidazol-1-yl-N,N-dimethyl ethanamine (0.35 g; 0.0010 mol; 1.0 equiv), 4-chloro-5-ethyl-5,7-dihydro-pyrrolo[2,3-d]pyrimidin-6-one (0.23 g; 0.0011 mol; 1.1 equiv), DIPEA (0.72 mL; 0.0041 mol; 4.0 equiv) in IPA (10 mL) and stir at 90° C. for 16 h. Quench the reaction with demineralized water and extract with EA. Evaporate the organic layer, purify over a silica gel column with 0-10% MeOH/DCM to give the title compound (0.13 g; 24.13%). MS (ES+): m/z=496 (M+H).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08148387B2
출처 데이터셋	uspto-grants-2012_04
ORD ID	ord-73108e1d496545288e9c16f1acb5350b
출처 메모	uspto-grants-2012_04