3-Hydroxy-2,2-diphenylpropanenitrile → HCID 18626554, 화합물

HRID 1685307노트

반응식

HRID 1685307 반응식
[OH:1][CH2:2][C:3]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[C:4]#[N:5].[H-].[H-].[H-].[H-].[Li+].[Al+3]>O1CCCC1>[NH2:5][CH2:4][C:3]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)[CH2:2][OH:1]

참가 물질

4

반응물 2

HCID 202707253-Hydroxy-2,2-diphenylpropanenitrileHCID 21226445Aluminium lithium hydride

생성물 1

HCID 18626554HCID 18626554, 화합물수율 88%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

A solution of 3-hydroxy-2,2-diphenylpropanenitrile in tetrahydrofuran (50 mL) was slowly added dropwise to a suspension of LAH in tetrahydrofuran (20 mL) at 23° C. The reaction was stirred overnight, then quenched with sodium sulfate decahydrate. The resulting solid was removed by filtration and the filtrate was concentrated to dryness to give the title material (0.45 g, 88%) as an oil which was used as such for the next reaction. 1H NMR (400 MHz, CDCl3) δ ppm: 2.49 (2H, s), 3.77 (1H, ddd, J=6.63, 4.23 and 2.53 Hz), 3.82 (2H, s), 4.30 (2H, s), 7.25-7.36 (10H, m). LC/MS (M+H)+: 228. HPLC ret. time (Condition A): 1.228 min.

후처리

  1. customquenched with sodium sulfate decahydrate
  2. customThe resulting solid was removed by filtration
  3. concentrationthe filtrate was concentrated to dryness

출처 및 근거

ORD 기록
ord-9caa8114c2f0461f936be1f2ba086ac4
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148400B2

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