Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diethyl Ether → tert-Butyl-(3-chloromethylsulfanyl-phenoxy)-dimethyl-silane
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diethyl Ether | HCID 3283 | — |
| 반응물 | Bromochloromethane | HCID 6333 | — |
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | Potassium bisulfate | HCID 516920 | — |
| 반응물 | 3-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]benzenethiol | HCID 21976868 | — |
| 생성물 | tert-Butyl-(3-chloromethylsulfanyl-phenoxy)-dimethyl-silane | HCID 58734012 | — |
반응 단계
DBU (914 mg, 6.0 mmol) was added to a solution of 3-(tert-Butyl-dimethyl-silanyloxy)-benzenethiol (1.00 g, 4.16 mmol) in bromo-chloro methane (5 ml) at room temperature. Stirring was continued for 2 hours and Et2O (50 ml) and 2M KHSO4 (30 ml) were added. The organic layer was separated, washed with 2M KHSO4 (30 ml) and brine (30 ml), dried (Na2SO4) and concentrated under reduced pressure. The resulting oil was analysed by 1H-NMR spectroscopy and was used without further purification. Yield: 1.01 g (84%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08148415B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-1507da1f180a4e8ea82054e9c26f141d |
| 출처 메모 | uspto-grants-2012_04 |