1,3-Benzodioxole-5-carbonyl chloride → N-(2-methylheptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide

반응식

[O:1]1[C:5]2[CH:6]=[CH:7][C:8]([C:10](Cl)=[O:11])=[CH:9][C:4]=2[O:3][CH2:2]1.[CH3:13][CH:14]([CH2:16][CH:17]([NH2:21])[CH2:18][CH2:19][CH3:20])[CH3:15]>>[CH3:13][CH:14]([CH2:16][CH:17]([NH:21][C:10]([C:8]1[CH:7]=[CH:6][C:5]2[O:1][CH2:2][O:3][C:4]=2[CH:9]=1)=[O:11])[CH2:18][CH2:19][CH3:20])[CH3:15]

참가 물질

반응물 2

HCID 27347491,3-Benzodioxole-5-carbonyl chloride

HCID 144181752-Methylheptan-4-amine

생성물 1

HCID 57330263N-(2-methylheptan-4-yl)benzo[d][1,3]dioxole-5-carboxamide

실험 절차

Prepared in a similar manner to example 1 using benzo[d][1,3]dioxole-5-carbonyl chloride and 2-methylheptan-4-amine (example 2a). 1H NMR (500 MHz, CDCl3): δ 0.93 (m, 9H); 1.38 (m, 5H); 1.53 (m, 1H); 1.66 (m, 1H); 4.21 (m, 1H); 5.61 (d, 1H); 6.01 (s, 2H); 6.82 (d, 1H); 7.26 (m, 2H). MS (278, M+H).

출처 및 근거

ORD 기록: ord-01f8007abead4b47b45ea3db47d2f019
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08148536B2

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