Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pentenone → 4-Methyl-5-(trimethylsilyl)pentan-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pentenone | HCID 12248 | — |
| 반응물 | HCID 178418680 | HCID 178418680 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4-Methyl-5-(trimethylsilyl)pentan-2-one | HCID 86643788 | 43% |
반응 단계
A solution of 8.00 g pent-3-en-2-one in 50 mL dry diethyl ether was dropped to a solution of 73.5 mL of chloro[(trimethylsilyl)methyl]magnesium (1.0M in diethyl ether) and 955 mg of CuBr at −5° C. under Argon. The mixture was stirred for 1 hour at room temperature. An aqueous work-up followed by silica gel chromatography yielded 5.20 g (43%) of a colourless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08148538B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-4a4bf6f84aee42c39db133cf56d29530 |
| 출처 메모 | uspto-grants-2012_04 |