3-chloro-4-fluoro-N,N-dimethylbenzenesulfonamide → (4-Chloro-3-{2-chloro-4-[(dimethylamino)sulfonyl]phenoxy}phenyl)acetic acid

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([N:12]([CH3:14])[CH3:13])(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1F.[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23]([OH:25])=[O:24])=[CH:18][C:17]=1[OH:26]>>[Cl:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][C:23]([OH:25])=[O:24])=[CH:18][C:17]=1[O:26][C:7]1[CH:6]=[CH:5][C:4]([S:9]([N:12]([CH3:14])[CH3:13])(=[O:11])=[O:10])=[CH:3][C:2]=1[Cl:1]

참가 물질

반응물 2

HCID 6977763-chloro-4-fluoro-N,N-dimethylbenzenesulfonamide

HCID 30171834-Chloro-3-hydroxyphenylacetic acid

생성물 1

HCID 16043202(4-Chloro-3-{2-chloro-4-[(dimethylamino)sulfonyl]phenoxy}phenyl)acetic acid

실험 절차

The title compound was prepared by the method of example 2 step (iii) using 3-chloro-4-fluoro-N,N-dimethylbenzenesulfonamide and the product of example 1 step (iii).

출처 및 근거

ORD 기록: ord-ee4ed5df12a3434fb8a10f30c2428374
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08148572B2

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