2-Chloro-1-fluoro-4-methylsulfonylbenzene → {3-Chloro-5-[2-chloro-4-(methylsulfonyl)phenoxy]phenyl}acetic acid

반응식

[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[C:6]([OH:8])[CH:7]=1.[CH3:13][S:14]([C:17]1[CH:22]=[CH:21][C:20](F)=[C:19]([Cl:24])[CH:18]=1)(=[O:16])=[O:15]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=[O:11])[CH:5]=[C:6]([O:8][C:20]2[CH:21]=[CH:22][C:17]([S:14]([CH3:13])(=[O:16])=[O:15])=[CH:18][C:19]=2[Cl:24])[CH:7]=1

참가 물질

반응물 2

HCID 213408802-Chloro-1-fluoro-4-methylsulfonylbenzene

HCID 596446192-(3-Chloro-5-hydroxyphenyl)acetic acid

생성물 1

HCID 57791939{3-Chloro-5-[2-chloro-4-(methylsulfonyl)phenoxy]phenyl}acetic acid

실험 절차

The title compound was prepared by the method of example 2 step (iii) using the product of step (iv) and 3-chloro-4-fluorophenyl methyl sulfone.

출처 및 근거

ORD 기록: ord-64b2cc1536474e9dabb867080a2565d4
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08148572B2

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