1,2-Difluoro-4-(methylsulfonyl)benzene → {3-Chloro-5-[2-fluoro-4-(methylsulfonyl)phenoxy]phenyl}acetic acid

HRID 1686408노트

반응식

HRID 1686408 반응식
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8](F)=[C:7]([F:12])[CH:6]=1)(=[O:4])=[O:3].[Cl:13][C:14]1[CH:15]=[C:16]([CH2:21][C:22]([OH:24])=[O:23])[CH:17]=[C:18]([OH:20])[CH:19]=1>>[Cl:13][C:14]1[CH:15]=[C:16]([CH2:21][C:22]([OH:24])=[O:23])[CH:17]=[C:18]([O:20][C:8]2[CH:9]=[CH:10][C:5]([S:2]([CH3:1])(=[O:4])=[O:3])=[CH:6][C:7]=2[F:12])[CH:19]=1

참가 물질

3

반응물 2

HCID 27827431,2-Difluoro-4-(methylsulfonyl)benzeneHCID 596446192-(3-Chloro-5-hydroxyphenyl)acetic acid

생성물 1

HCID 16123205{3-Chloro-5-[2-fluoro-4-(methylsulfonyl)phenoxy]phenyl}acetic acid

실험 절차

The title compound was prepared by the method of example 2 step (iii) using 3,4-difluorophenyl methyl sulfone and the product of example 18 step (iv).

출처 및 근거

ORD 기록
ord-67ae545a11364978bcfa840c2289d39d
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148572B2

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