Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4,5-Trichloropyrimidine → (2,5-Dichloro-pyrimidin-4-yl)-(2-fluoro-6-methoxy-phenyl)-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4,5-Trichloropyrimidine | HCID 237259 | — |
| 반응물 | 2-Fluoro-6-methoxyaniline | HCID 459253 | — |
| 생성물 | (2,5-Dichloro-pyrimidin-4-yl)-(2-fluoro-6-methoxy-phenyl)-amine | HCID 86633994 | — |
반응 단계
(2,5-Dichloro-pyrimidin-4-yl)-(2-fluoro-6-methoxy-phenyl)-amine was prepared from 2,4,5-Trichloro-pyrimidine and 2-Fluoro-6-methoxyaniline in an analogous manner to Example 1230a. Title product was obtained as an off white solid (3.80 g, 62%). MP=133-135. LCMS 289.03 (M+H), HPLC purity=94%, 1H-NMR (DMSO-d6, 400 MHz) δ 9.24 (s, 1H), 8.35 (s, 1H), 7.39-7.35 (m, 1H), 7.00-6.91 (m, 2H), 3.80 (s, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08148391B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-d02b6372d89d4ce18f884f47dfb8e400 |
| 출처 메모 | uspto-grants-2012_04 |