2,4,5-Trichloropyrimidine → HCID 86634002, 화합물

HRID 1687658

반응식

HRID 1687658 반응식
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([N:9]2[CH2:14][CH2:13][O:12][CH2:11][CH2:10]2)[C:3]=1[NH2:15].[Cl:16][C:17]1[N:22]=[C:21](Cl)[C:20]([Cl:24])=[CH:19][N:18]=1>>[Cl:16][C:17]1[N:22]=[C:21]([NH:15][C:3]2[C:4]([N:9]3[CH2:14][CH2:13][O:12][CH2:11][CH2:10]3)=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])[C:20]([Cl:24])=[CH:19][N:18]=1

참가 물질

3

반응물 2

HCID 2372592,4,5-TrichloropyrimidineHCID 672646582,4-Difluoro-6-morpholin-4-yl-phenylamine

생성물 1

HCID 86634002HCID 86634002, 화합물

실험 절차

(2,5-Dichloro-pyrimidin-4-yl)-(2,4-difluoro-6-morpholin-4-yl-phenyl)-amine was prepared from 2,4-Difluoro-6-morpholin-4-yl-phenylamine and 2,4,5-Trichloropyrimidine in an analogous manner to Example 1230a. Title compound was isolated as an off-white foam (337 mg, 57%) HPLC 97% purity, LCMS 363.10 (M+H), 1H-NMR (CDCl3, 400 MHz) δ 8.23 (s, 1H), 6.90 (s, 1H), 6.72 (dd, 1H), 6.64 (d, J=9.6 Hz, 1H), 3.79-3.77 (m, 4H), 2.90-2.87 (m, 4H).

출처 및 근거

ORD 기록
ord-c000ea8e16894e90b4731b51e22dfd92
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148391B2

연결된 노트

불러오는 중…