2-{[(Tert-butoxy)carbonyl]amino}-3-(trifluoromethoxy)benzoic acid → 2-amino-3-(trifluoromethoxy)benzoic Acid

HRID 1688083노트

반응식

HRID 1688083 반응식
C(OC([NH:8][C:9]1[C:17]([O:18][C:19]([F:22])([F:21])[F:20])=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([OH:13])=[O:12])=O)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:8][C:9]1[C:17]([O:18][C:19]([F:20])([F:21])[F:22])=[CH:16][CH:15]=[CH:14][C:10]=1[C:11]([OH:13])=[O:12]

참가 물질

3

반응물 1

HCID 109033232-{[(Tert-butoxy)carbonyl]amino}-3-(trifluoromethoxy)benzoic acid

생성물 1

HCID 117461722-amino-3-(trifluoromethoxy)benzoic Acid수율 71%

시약·촉매·용매 1

HCID 21863450Trifluoroacetic acid methylene chloride용매

실험 절차

A solution of 2-tert-butoxycarbonylamino-3-trifluoromethoxy-benzoic acid (0.8 g, 2.5 mmol) in 30% v/v TFA/methylene chloride (50 mL) was stirred at room temperature for 1 h. Concentration of the mixture gave 2-amino-3-trifluoromethoxy-benzoic acid (0.39 g, 71%): 1H NMR (300 MHz, CDCl3) δ 7.88 (d, 1H), 7.34 (d, 1H), 6.63 (t, 1H), 6.04 (br, 2H).

출처 및 근거

ORD 기록
ord-286565aea67140a58bb39ee73a5434e4
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148391B2

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