Ammonium Hydroxide → 4-Methyloxazole-5-carboxamide

HRID 1688334

반응식

HRID 1688334 반응식
[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[C:7]([O:9]CC)=O.[OH-].[NH4+:13]>>[CH3:1][C:2]1[N:3]=[CH:4][O:5][C:6]=1[C:7]([NH2:13])=[O:9]

참가 물질

3

반응물 2

HCID 14923Ammonium HydroxideHCID 88558Ethyl 4-methyloxazole-5-carboxylate

생성물 1

HCID 785814-Methyloxazole-5-carboxamide

실험 절차

A mixture of ethyl 4-methyloxazole-5-carboxylate (7.8 g, 50 mmoles) and ammonium hydroxide in a seal tube was stirred at rt for 12 hours. After completion of the reaction, solid was filtered and washed with water. The aqueous was extracted with ethyl acetate. The organic extract was dried and concentrated and combined with the filtered solid. Yield: 4.1 g (47%) 1H NMR (400 MHz, CDCl3): δ 2.38 (s, 3H), 7.92 (s, 1H). LCMS: (ES+) m/z=126.7 (M)+

후처리

  1. customAfter completion of the reaction, solid
  2. filtrationwas filtered
  3. washwashed with water
  4. extractionThe aqueous was extracted with ethyl acetate
  5. extractionThe organic extract
  6. customwas dried
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-fe3d402ed9894436ac01d53ae19a3e8f
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148382B2

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