2-(4-Chloro-3-(hydroxymethyl)phenyl)ethanol → 2-Chloro-5-(2-hydroxyethyl)benzaldehyde

HRID 1689358

반응식

HRID 1689358 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][C:3]=1[CH2:11][OH:12]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][OH:10])=[CH:4][C:3]=1[CH:11]=[O:12]

참가 물질

4

반응물 1

HCID 579892912-(4-Chloro-3-(hydroxymethyl)phenyl)ethanol

생성물 1

HCID 579893312-Chloro-5-(2-hydroxyethyl)benzaldehyde

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

Manganese (IV) dioxide (1.00 g) was added to a solution of 2-(4-chloro-3-(hydroxymethyl)phenyl)ethanol (example 61, step b) (0.200 g) in DCM (5 mL), and the resulting suspension was stirred at room temperature overnight. The mixture was then filtered through Celite, washing the residue well with DCM. The filtrate and washings were concentrated in vacuo to afford the subtitled compound as a colourless oil. Yield 0.197 g.

후처리

  1. filtrationThe mixture was then filtered through Celite
  2. washwashing the residue well with DCM
  3. concentrationThe filtrate and washings were concentrated in vacuo

출처 및 근거

ORD 기록
ord-6185c93af1964385aa4a3a50e2ca0c88
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08148373B2

연결된 노트

불러오는 중…