Isopropyl iodide → 1-(3-isopropoxyphenyl)ethanone

HRID 1690191노트

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HRID 1690191 반응식
[OH:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:17][CH:18](I)[CH3:19]>CC(C)=O>[CH3:17][CH:18]([O:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1)[CH3:19]

참가 물질

5

반응물 3

HCID 6362Isopropyl iodideHCID 84873-HydroxyacetophenoneHCID 11430Potassium Carbonate

생성물 1

HCID 51728431-(3-isopropoxyphenyl)ethanone수율 94%

시약·촉매·용매 1

HCID 180Acetone용매

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온도
70 °C

실험 절차

1-(3-Hydroxyphenyl)ethanone (1.36 g, 10 mmol) was dissolved in acetone (50 mL), and the resultant mixture was sequentially added with potassium carbonate (2.76 g, 20 mmol) and 1-methylethyl iodide (1.5 mL, 15 mmol), and stirred at 70° C. overnight. The reaction solution was filtered, washed with acetone, and concentrated in vacuo. The resultant residue was added with water and ethyl acetate and extracted with ethyl acetate. The organic layer was washed with 1N aqueous solution of sodium hydroxide and brine, dried using anhydrous sodium sulfate, and concentrated in vacuo. 1-(3-(1-methylethoxy)phenyl)ethanone (1.67 g, yield 94%) was obtained as a yellow oil.

후처리

  1. filtrationThe reaction solution was filtered
  2. washwashed with acetone
  3. concentrationconcentrated in vacuo
  4. additionThe resultant residue was added with water and ethyl acetate
  5. extractionextracted with ethyl acetate
  6. washThe organic layer was washed with 1N aqueous solution of sodium hydroxide and brine
  7. customdried
  8. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-70a4a854f3314b758e000aab99760b8c
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153634B2

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