Hydantoin, 5-(p-isopropoxyphenyl)-5-methyl- → HCID 86639424, 화합물

반응식

[CH2:1](C1C=C(C(OCOC)(C(F)(F)F)C(F)(F)F)C=C(CCC)C=1O)CC.ClC1C=C(B(O)O)C=CN=1.Cl[C:38]1[CH:43]=[C:42]([O:44][C:45]2[C:50]([CH2:51][CH2:52][CH3:53])=[CH:49][C:48]([C:54]([O:63]COC)([C:59]([F:62])([F:61])[F:60])[C:55]([F:58])([F:57])[F:56])=[CH:47][C:46]=2[CH2:67][CH2:68][CH3:69])[CH:41]=[CH:40][N:39]=1.[CH3:70][C:71]1([C:78]2[CH:83]=[CH:82][C:81]([O:84][CH:85]([CH3:87])[CH3:86])=[CH:80][CH:79]=2)[NH:75][C:74](=[O:76])[NH:73][C:72]1=[O:77]>>[F:56][C:55]([F:57])([F:58])[C:54]([C:48]1[CH:47]=[C:46]([CH2:67][CH2:68][CH3:69])[C:45]([O:44][C:42]2[CH:41]=[CH:40][N:39]=[C:38]([CH2:1][N:73]3[C:72](=[O:77])[C:71]([C:78]4[CH:83]=[CH:82][C:81]([O:84][CH:85]([CH3:87])[CH3:86])=[CH:80][CH:79]=4)([CH3:70])[NH:75][C:74]3=[O:76])[CH:43]=2)=[C:50]([CH2:51][CH2:52][CH3:53])[CH:49]=1)([OH:63])[C:59]([F:62])([F:61])[F:60]

참가 물질

반응물 4

HCID 3052153Hydantoin, 5-(p-isopropoxyphenyl)-5-methyl-

HCID 51515952-Chloropyridine-4-boronic acid

HCID 59234895HCID 59234895, 화합물

HCID 86639425HCID 86639425, 화합물

생성물 1

HCID 86639424HCID 86639424, 화합물

실험 절차

2,6-dipropyl-4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl]phenol was used in place of 4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2-propylphenol, and 2-chloropyridine-4-boronic acid was used in place of 3-(hydroxymethyl)phenylboronic acid in Preparation Example 3 for a similar reaction and treatment, and the obtained 2-chloro-4-(4-(1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl)-2,6-dipropylphenoxy) pyridine and 5-methyl-5-(4-(1-methylethoxy)phenyl)imidazolidine-2,4-dione were used for a similar reaction and treatment as Example 40, and the title compound was obtained as a colorless oil.