Cyclohexyl isocyanate → 1-Butyl-1-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-urea

반응식

[CH2:1]([NH:5][C:6]1[N:7]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[N:8]=[C:9]2[C:14]=1[CH:13]=[CH:12][CH:11]=[CH:10]2)[CH2:2][CH2:3][CH3:4].[CH:22]1([N:28]=[C:29]=[O:30])[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH2:1]([N:5]([C:6]1[N:7]([C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[N:8]=[C:9]2[C:14]=1[CH:13]=[CH:12][CH:11]=[CH:10]2)[C:29]([NH:28][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)=[O:30])[CH2:2][CH2:3][CH3:4]

참가 물질

반응물 2

HCID 18502Cyclohexyl isocyanate

HCID 66905446butyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine

생성물 1

HCID 451106161-Butyl-1-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-3-cyclohexyl-urea

실험 절차

In analogy to the procedure described in example 1.2, butyl-[2-(4-chloro-phenyl)-2H-indazol-3-yl]-amine was reacted with cyclohexylisocyanate ([3173-53-3]) to give the title compound as yellow solid. MS: m/e=425.3 [M+H+].

출처 및 근거

ORD 기록: ord-f2350aa8c89f4f6cac57c9a25bea3c50
출처 데이터셋: uspto-grants-2012_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08153663B2

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