Ethyl 3-[4-hydroxy-3-(3-methoxypropoxy)phenyl]acrylate → Ethyl 3-[4-hydroxy-3-(3-methoxypropoxy)phenyl]propanoate

HRID 1690608노트

반응식

HRID 1690608 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][C:3]=1[O:15][CH2:16][CH2:17][CH2:18][O:19][CH3:20]>C(O)C>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:4][C:3]=1[O:15][CH2:16][CH2:17][CH2:18][O:19][CH3:20]

참가 물질

3

반응물 1

HCID 66907011Ethyl 3-[4-hydroxy-3-(3-methoxypropoxy)phenyl]acrylate

생성물 1

HCID 66907182Ethyl 3-[4-hydroxy-3-(3-methoxypropoxy)phenyl]propanoate수율 76.4%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Ethyl 3-[4-hydroxy-3-(3-methoxypropoxy)phenyl]acrylate (16 g, 57 mmol) was dissolved in ethanol (190 mL) in a Parr apparatus. Nitrogen was bubbled for 15 minutes and Pd/C 10% (0.8 g) was added. The reaction mixture was submitted to hydrogenation under H2 atmosphere (3 bars) until the end of H2 consumption. The palladium was then filtered and the solvent was evaporated under reduced pressure to yield 12.3 g (76%) of the desired product as a colorless oil.

후처리

  1. customNitrogen was bubbled for 15 minutes
  2. additionPd/C 10% (0.8 g) was added
  3. customuntil the end of H2 consumption
  4. filtrationThe palladium was then filtered
  5. customthe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-daceb19e62f74f98af860b07cf6a5017
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153647B2

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