methyl 1-oxo-2,3-dihydro-1H-indene-5-carboxylate → 7-(4-Butylphenyl)-5,10-dihydroindeno[1,2-b]indole-2-carboxylic acid

HRID 1690683노트

반응식

HRID 1690683 반응식
Cl.[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([NH:18]N)[CH:13]=2)=[CH:8][CH:7]=1)[CH2:3][CH2:4][CH3:5].C[O:21][C:22]([C:24]1[CH:25]=[C:26]2[C:30](=[CH:31][CH:32]=1)[C:29](=O)[CH2:28][CH2:27]2)=[O:23]>>[CH2:2]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[CH:16][C:15]3[C:28]4[CH2:27][C:26]5[C:30](=[CH:31][CH:32]=[C:24]([C:22]([OH:23])=[O:21])[CH:25]=5)[C:29]=4[NH:18][C:14]=3[CH:13]=2)=[CH:8][CH:7]=1)[CH2:3][CH2:4][CH3:5]

참가 물질

3

반응물 2

HCID 10375253methyl 1-oxo-2,3-dihydro-1H-indene-5-carboxylateHCID 66904838HCID 66904838, 화합물

생성물 1

HCID 160467547-(4-Butylphenyl)-5,10-dihydroindeno[1,2-b]indole-2-carboxylic acid

실험 절차

By reacting (4′-Butyl-biphenyl-3-yl)-hydrazine hydrochloride (example 70, step 1) and 1-oxo-indan-5-carboxylic acid methyl ester as described in example 1 followed by hydrolysis as described in example 2 the title material is obtained in similar yield. ESMS m/z 382.1 (M+H+).

후처리

  1. customfollowed by hydrolysis
  2. customis obtained in similar yield

출처 및 근거

ORD 기록
ord-68e559a41c104bf3be629e28ccc6e29a
출처 데이터셋
uspto-grants-2012_04
특허 번호
US08153671B2

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