Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 6-Nitro-5-vinyl-indan-1-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Dibutyl Vinylboronate (stabilized with Phenothiazine) | HCID 236543 | — |
| 반응물 | 5-bromo-6-nitro-2,3-dihydro-1H-inden-1-one | HCID 53485149 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Oxolane--water (1/1) | HCID 21881883 | — |
| 생성물 | 6-Nitro-5-vinyl-indan-1-one | HCID 57618480 | 79% |
반응 단계
A solution of 5-bromo-6-nitro-indan-1-one (58 mg, 0.23 mmol), (J. Med. Chem., 2003, 46, 399-408), vinylboronic acid dibutyl ester (74 μL, 0.34 mmol), Pd(PPh3)2Cl2 (7.8 mg, 0.0011 mmol), and Na2CO3 (167 mg, 1.57 mmol) in 4:1 THF/H2O (1.4 mL/360 μL) was heated to 80° C. overnight. The crude reaction was filtered over Celite and extracted with EtOAC. The organic phase was dried (MgSO4), filtered, and concentrated. The crude material was chromatographed (SiO2) to afford 36 mg (79%) of 6-Nitro-5-vinyl-indan-1-one; LC/MS calculated for [M+H]+ C11H9NO2: 204.1, found: 204.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08153671B2 |
| 출처 데이터셋 | uspto-grants-2012_04 |
| ORD ID | ord-1e8c2994e86a498d92cf684018961c13 |
| 출처 메모 | uspto-grants-2012_04 |